SDMA: Innovative kidney function biomarker

SDMA (symmetric dimethylarginine) is a renal biomarker specific to kidney function. It has proven to be a more reliable indicator of kidney function than creatinine, enabling veterinarians to detect both acute kidney injury (AKI) and chronic kidney disease (CKD) earlier than ever before.1-5 The International Renal Interest Society (IRIS) says it also helps in determining the most effective treatment recommendations for advancing disease.6

Three key attributes of SDMA make it a more reliable kidney function test:

  • Biomarker for kidney function
    SDMA is excreted by the kidneys. SDMA more accurately reflects glomerular filtration rate (GFR) in dogs and cats.1-3,7
  • Earlier than creatinine
    SDMA increases as early as 25% loss of kidney function,2 making SDMA more reliable in both acute or active kidney injury and chronic kidney disease.1-3 Creatinine cannot identify kidney issues until almost 75% of kidney function is lost.2,3
  • Specific for kidney function
    SDMA is less impacted by extrarenal factors than creatinine, including body condition, advanced age, and disease state.4,5

    SDMA is also not affected by lean body mass, making it more reliable for assessing kidney function in animals with chronic kidney disease or other conditions that result in weight and muscle loss, such as hyperthyroidism.4,5

IRIS guidelines
The IDEXX SDMA Test is now included in the International Renal Interest Society (IRIS) Chronic Kidney Disease (CKD) Staging and Treatment Guidelines as a useful adjunct for diagnosing CKD and for helping to determine treatment for the appropriate stage of CKD.6

Simple to order
The IDEXX SDMA Test is included in all IDEXX Reference Laboratories routine reference laboratory chemistry panels at no additional charge. It can also be easily ordered as a stand-alone test to complement your in-house IDEXX chemistry panel.

The IDEXX SDMA Test is now included in the International Renal Interest Society (IRIS) guidelines for chronic kidney disease.

Find 2 times more disease

IDEXX SDMA Test data shows that kidney disease is over 2 times more common than previously reported.8 View white paper >

Case studies

Zeke

Zeke’s creatinine results were influenced by both metabolism and body mass, but an increased SDMA result detected CKD along with his hyperthyroidism. Read more >

Scarlet

Scarlet’s persistently elevated SDMA concentrations led to the diagnosis and early treatment of kidney disease, despite normal creatinine results. Read more >

Bess

Bess’s case highlights the importance of SDMA testing in older patients. SDMA is not influenced by muscle mass and is more reliable than creatinine in detecting kidney disease. Read more >

Watch

Read

Learn

References
  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/pdf/staging-of-ckd.pdf. Accessed September 30, 2016.
  7. Yerramilli M, Yerramilli M, Obare E, Jewell DE, Hall JA. Symmetric dimethylarginine (SDMA) increases earlier than serum creatinine in dogs with chronic kidney disease (CKD). [ACVIM Abstract NU-42]. J Vet Intern Med. 2014;28(3):1084–1085. Accessed January 14, 2015.
  8. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.