IDEXX SDMA testing

Gain deeper insights into kidney function with IDEXX SDMA testing so you can confidently take action.

Welcome to the IDEXX SDMA Resource Center

Find everything you need to use, implement, and order SDMA.

What are their kidneys telling you?


Listen closer with IDEXX SDMA

What are their kidneys telling you?


Listen closer with IDEXX SDMA

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer
Drug toxicity

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

Run SDMA every time you run creatinine and BUN

A new standard of care for monitoring kidney function that detects and reflects disease
  • SDMA is a sensitive indicator of kidney function that detects as little as 25% loss of function.1,2
  • SDMA is more reliable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions.4,5
  • SDMA is an earlier indicator of progressive kidney function loss, often increasing before other parameters.1–3
  • An increased SDMA may also serve as an indicator of concurrent disease that may have a secondary impact on kidney function.6

What to do when SDMA is increased

An increased SDMA indicates impaired GFR, which helps detect both acute and chronic diseases within the kidneys or reflects secondary diseases causing a negative impact on kidney function.

The IDEXX SDMA Test Algorithm will help you take the appropriate steps towards confirming disease and diagnosis when SDMA is increased.

Download: IDEXX SDMA Test Algorithm

IDEXX SDMA algorithm and IMM protocol

When SDMA is increased, but all other markers are normal, don't hesitate.

Take action: Investigate, manage, and monitor. Get the details.

Follow the IRIS guidelines for staging and treating CKD

Overview of the International Renal Interest Society (IRIS) guidelines for Chronic Kidney Disease (CKD)

The International Renal Society (IRIS) chronic kidney disease (CKD) guidelines recognize the importance of SDMA for both diagnosis and treatment. 7 

Learn more about the guidelines

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analyzers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

Note: SDMA is symmetric dimethylarginine.

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  7. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines (modified 2019). www.iris-kidney.com/guidelines. Accessed April 4, 2019.