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IDEXX SDMA testing

Medical claims: IDEXX SDMA

• SDMA detects diseases of the kidney1–13
• SDMA reflects other disease processes affecting the kidneys8,9,14–26
References
  1. Nabity MB, Lees GE, Boggess MM, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044. doi:10.1111/jvim.12835
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683. doi:10.1111/jvim.12445
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802. doi:10.1111/jvim.13942
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596. doi:10.1016/j.tvjl.2014.10.021
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814. doi:10.1111/jvim.12607
  6. Dahlem DP, Neiger R, Schweighauser, et al. Plasma symmetric dimethylarginine concentrations in dogs with acute kidney injury and chronic kidney disease. J Vet Intern Med. 2017;31(3):799–804. doi:10.1111/jvim.14694
  7. Yerramilli M, Farace G, Quinn J, Yerramilli M. Kidney disease and the nexus of chronic kidney disease and acute kidney injury: The role of novel biomarkers as early and accurate diagnostics. Vet Clin North Am Small Anim Pract. 2016;46(6):961–993. doi:10.1016/j.cvsm.2016.06.011
  8. Bartges J, Polzin D, eds. Nephrology and Urology of Small Animals. Ames, IA: Wiley-Blackwell; 2011.
  9. Ettinger SJ, Feldman EC, Côté E. Textbook of Veterinary Internal Medicine. 8th ed. St Louis, MO: Elsevier Saunders; 2017.
  10. Berent A. Feline ureteral obstruction: diagnosis and management. In: Drobatz K, Hopper K, Silverstein DC, eds. Textbook of Small Animal Emergency Medicine. 3rd edition. Ames, IA: Wiley-Blackwell; 2018:627–633.
  11. Lulich JP, Berent AC, Adams LG, Westropp JL, Bartges JW, Osborne CA. ACVIM small animal consensus recommendations on the treatment and prevention of uroliths in dogs and cats. J Vet Intern Med. 2016;30:1564–1574. doi:10.1111/jvim.14559
  12. Hall JA, Yerramilli M, Obare E, Li J, Yerramilli M, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in cats with kidney stones. PLoS One. 2017;12(4):e0174854. doi:10.1371/journal.pone.0174854
  13. IRIS Canine GN Study Group Diagnosis Subgroup, Littman MP, Daminet S, Grauer GF, Lees GE, van Dongen AM. Consensus recommendations for the diagnostic investigation of dogs with suspected glomerular disease. J Vet Intern Med. 2013;27(Supp 1):S19–S26. doi:10.1111/jvim.12223
  14. Szlosek D, Robertson J, Quimby J, et al. A retrospective evaluation of the relationship between symmetric dimethylarginine, creatinine and body weight in hyperthyroid cats. PLoS One. 2020;15(1):e0227964. doi:10.1371/journal.pone.0227964
  15. Peterson M, Varela F, Rishniw M, and Polzin DJ. Evaluation of serum symmetric dimethylarginine concentration as a marker for masked chronic kidney disease in cats with hyperthyroidism. J Vet Intern Med. 2018;32(1):295–304. doi:10.1111/jvim.15036
  16. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  17. Acierno MJ, Brown S, Coleman AE, et al. ACVIM consensus statement: guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J Vet Intern Med. 2018;32(6):1803–1822. doi:10.1111/jvim.1533111
  18. Taylor SS, Sparkes AH, Briscoe K, et al. ISFM consensus guidelines on the diagnosis and management of hypertension in cats [published correction appears in J Feline Med Surg. 2018;20(6):NP1]. J Feline Med Surg. 2017;19(3):288–303. doi:10.1177/1098612X17693500
  19. Orvalho JS, Cowgill LD. Cardiorenal syndrome: Diagnosis and management. Vet Clin North Am Small Anim Pract. 2017;47(5):1083–1102. doi:10.1016/j.cvsm.2017.05.004
  20. Liu M, Köster LS, Fosgate GT, et al. Cardiovascular-renal axis disorder and acute-phase proteins in cats with congestive heart failure caused by primary cardiomyopathy. J Vet Intern Med. 2020;34(3):1078–1090. doi:10.1111/jvim.15757
  21. Winkler MS, Nierhaus A, Rösler G, et al. Symmetrical (SDMA) and asymmetrical dimethylarginine (ADMA) in sepsis: high plasma levels as combined risks markers for sepsis survival. Crit Care. 2018;22(1):216. doi:10.1186/s13054-018-2090-1
  22. Coyne M, Drake C, McCrann DJ. The association between symmetric dimethylarginine concentrations and neoplasia in dogs and cats [ACVIM Abstract O05]. J Vet Intern Med. 2018;32(6):2216–2217. doi:10.1002/jvim.15319
  23. Yerramilli M, Yerramilli M, Farace G, et al. Symmetric Dimethylarginine (SDMA) as kidney biomarker in canine and feline cancer [ECVIM Abstract ESVNU-P-4]. J Vet Intern Med. 2017;31(1):251. doi:10.1111/jvim.14600
  24. Drake C, Coyne M, McCrann DJ, Buch J, Mack R. Risk of development of chronic kidney disease after exposure to Borrelia burgdorferi and Anaplasma spp. Top Companion Anim Med. 2021;42:100491. doi:10.1016/j.tcam.2020.100491
  25. Burton W, Drake C, Ogeer J, et al. Association between exposure to Ehrlichia spp. and risk of developing chronic kidney disease in dogs. J Am Anim Hosp Assoc. 2020;56(3):159–164. doi:10.5326/JAAHA-MS-7012
  26. Giapitzoglou S , Saridomichelakis MN, Leontides LS, et al. Evaluation of serum symmetric dimethylarginine as a biomarker of kidney disease in canine leishmaniosis due to Leishmania infantum. Vet Parasitol. 2020;277:109015. doi:10.1016/j.vetpar.2019.109015
  27. Koch A, Weiskirchen R, Bruensing J, et al. Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis. Mediators Inflamm. 2013;2013:413826. doi:10.1155/2013/413826
  28. Perini-Perera S, Del-Ángel-Caraza J, Pérez-Sánchez AP, Quijano-Hernández IA, Recillas-Morales S. Evaluation of chronic kidney disease progression in dogs with therapeutic management of risk factors. Front Vet Sci. 2021;8:621084. doi:10.3389/fvets.2021.621084