IDEXX SDMA testing

An elevated SDMA indicates impaired GFR

Identify declines in kidney function confidently and consistently with SDMA

  • SDMA is a highly sensitive marker of glomerular filtration rate (GFR).1–4
  • An increase clearly indicates that kidney function has declined.1–4
  • Investigating an increase helps determine primary or secondary causes.
  • Secondary causes of impaired GFR can often be treated effectively.
  • Without intervention, patients are at risk for long-term kidney damage.
     

Order SDMA now

 

What are their kidneys telling you?

Listen closer with IDEXX SDMA

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer
Drug toxicity

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

  • An elevated SDMA* is an indication of an impaired GFR, and thus detects diseases of the kidney and reflects other disease processes affecting the kidneys.
  • Incorporating this testing as a standard part of your routine chemistry panel helps you identify, treat, and more effectively manage kidney health to improve—and potentially extend—the lives of your patients.
     

Review cases

Increases in SDMA are common and need to be addressed

Increased SDMA was the third-most common abnormality in an evaluation of results from more than 1 million medical cases (excluding wellness).6

40%–70% more preventive care profiles demanded follow-up when IDEXX SDMA testing was added to a chem 22 and complete blood count (CBC).6

Kidney abnormalities are the most common finding in preanesthetic blood work,6 making SDMA an essential part of any preanesthetic workup (routine and emergency cases).

A mild SDMA increase can be a medical turning point
 

After a single mild increase in SDMA:

Results of a retrospective analysis in which 16,523 dogs and 16,454 cats had three or more SDMA results, the first result was within the reference interval.

Read: A mild SDMA increase can be a medical turning point

Following a normal result for SDMA and creatinine, these patients had two elevated SDMA results in a row (more than 14 days and less than 12 months apart).

Restoration of GFR (SDMA 0–14 µg/dL) can be due to treatment, compensatory mechanisms, or repair from a minor kidney injury.

When to look for increased SDMA

Medical cases

In over 1 million medical cases (excluding wellness), increased SDMA was the third-most common abnormality.6 Review the data

Hyperthyroid patients

SDMA is more useful than creatinine and BUN in hyperthyroid patients because it is not impacted by changes in muscle mass.4,5 

Vector-borne disease-positive patients

Data shows that patients exposed to tick-borne diseases are at increased risk of developing CKD.6 Get details from two studies

Wellness examinations

(Especially in senior cats)

Signs of kidney injury and/or decline are not easily revealed by a physical examination or a CBC alone. Read Reese's case

Preanesthetic blood work

(Regardless of age)

Even seemingly healthy patients should receive an SDMA test prior to receiving anesthesia.

Read Molly's case

Annual examinations

A single increase in SDMA warrants further investigation and possible management. Read Jimmy's case

What to do when SDMA is increased and other markers are normal

IDEXX SDMA algorithm and IMM protocol
Use the IDEXX SDMA algorithm to interpret results
Overview of the International Renal Interest Society (IRIS) guidelines for Chronic Kidney Disease (CKD)
Follow the IRIS guidelines to stage and treat chronic kidney disease (CKD)

Peer-reviewed studies support SDMA

More sensitive than creatinine1–4

SDMA is a sensitive indicator of renal function in dogs. Creatinine doesn't increase until up to 75% loss of kidney function, whereas SDMA increases with as little as 25% loss of kidney function.

Less impacted by extrarenal factors4,5

Unlike creatinine and BUN, SDMA is not affected by factors that can overestimate GFR. SDMA is specific for kidney function and less impacted by extrarenal factors, including body condition, advanced age, and disease state.

More reliable than creatinine1–5

SDMA is more reliable than creatinine in aging cats with muscle wasting.4,5

Increases earlier than creatinine in cats2

Results of a retrospective longitudinal study2 that includes 21 cats with chronic kidney disease (CKD) show that SDMA increased 17 months earlier than serum creatinine on average (range 1.5–48 months).

Increases earlier than creatinine in dogs3

SDMA increases earlier than creatinine in dogs with CKD. Results of a retrospective longitudinal study3 that includes 19 dogs with CKD show that SDMA increased 9.8 months earlier than serum creatinine on average (range 2.2–27 months).

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analyzers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories
The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analyzers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

Note: SDMA is symmetric dimethylarginine.

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  7. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines. Accessed January 22, 2020.