IDEXX SDMA testing

What are their kidneys telling you?


Listen closer with IDEXX SDMA

What are their kidneys telling you?


Listen closer with IDEXX SDMA

Detects

diseases of
the kidney sooner1–3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

Detects

diseases of
the kidney sooner1-3

Chronic kidney disease
Acute kidney injury
Pyelonephritis
Upper urinary obstruction
Kidney stones
Glomerulonephritis
Congenital disease

Reflects

other disease processes
affecting the kidneys6

Hyperthyroidism
Vector-borne disease
Systemic hypertension
Cardiorenal syndrome
Lower urinary obstruction
Sepsis
Cancer

That's why it's essential to run SDMA every time you run creatinine and BUN

A new standard of care for monitoring kidney function that detects and reflects disease
  • SDMA is a sensitive indicator of kidney function that detects as little as 25% loss of function.1,2
  • SDMA is more relable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions.4,5
  • SDMA is an earlier indicator of progressive kidney function loss, often increasing before other parameters.1–3
  • An increased SDMA may also serve as an indicator of concurrent disease that may have a secondary impact on kidney function.6

Common cases when SDMA is essential

Look for increased SDMA, especially in medical cases.

Data from over 1 million medical cases, excluding wellness, found increased SDMA was the third most common abnormality. SDMA identified 2x more patients with reduced glomular filtration rate (GFR) than creatinine.

Read the details

Look for increased SDMA when other results are normal.
SDMA detected Bess' chronic kidney disease (CKD), allowing treatment to begin earlier.

Bess showed some moderate periodontal disease, and other examination parameters were within normal limits.

Read Bess's case study

Look for increased SDMA in hyperthyroid patients.
SDMA helped detect Zeke's CKD.

SDMA is more useful in diagnosing hyperthyroid cats than creatinine and BUN alone because SDMA is not impacted by changes in muscle mass.4,5  Learn more about hyperthyroid cats and the IDEXX SDMA Test.

Read Zeke's case study

Look for increased SDMA in VBD-positive patients.

Learn more about why SDMA is an essential test in helping to detect CKD in dogs with certain vector-borne diseases (VBDs).

Read about two studies
Use SDMA when assessing highly muscled dogs.

SDMA helped to rule out kidney disease in Mary Jane, a highly muscled dog with increased creatinine.

Read Mary Jane's case study
Use pediatric-specific intervals for SDMA.

In puppies, the IDEXX SDMA Test reference interval has been determined to be slightly higher than the adult reference interval. The adult cat reference interval of 0–14 µg/dL is appropriate for use in kittens. 

Read the diagnostic update

Look for increased SDMA in wellness examinations for senior cats.

SDMA helped lead to Reese’s diagnosis and treatment of suspect pyelonephritis and improved kidney function.

Read Reese's case study

Run SDMA with preanesthetic blood work, regardless of age.

SDMA helped diagnose an active kidney injury during preanesthetic testing for this puppy’s routine ovariohysterectomy.

Read Molly's case study

Run SDMA blood work for annual exams.

SDMA led to the discovery of CKD with hypertension when it was included as part of Jimmy’s annual checkup.

Read Jimmy's case study

Peer-reviewed studies support SDMA

More sensitive than creatinine1–4

SDMA is a sensitive indicator of renal function in dogs. Creatinine doesn't increase until up to 75% loss of kidney function, whereas SDMA increases with as little as 25% loss of kidney function.

Less impacted by extrarenal factors4,5

Unlike creatinine and BUN, SDMA is not affected by factors that can overestimate GFR. SDMA is specific for kidney function and less impacted by extrarenal factors, including body condition, advanced age, and disease state.

More reliable than creatinine1–5

SDMA is more reliable than creatinine in aging cats with muscle wasting.4,5

Increases earlier than creatinine in cats2

Results of a retrospective longitudinal study2 that includes 21 cats with CKD show that SDMA increased 17 months earlier than serum creatinine on average (range 1.5–48 months).

Increases earlier than creatinine in dogs3

SDMA increases earlier than creatinine in dogs with chronic kidney disease (CKD). Results of a retrospective longitudinal study3 that includes 19 dogs with CKD show that SDMA increased 9.8 months earlier than serum creatinine on average (range 2.2–27 months).

Two options: same reliable results

The in-house Catalyst SDMA Test for use with the Catalyst One and Catalyst Dx chemistry analyzers
The IDEXX SDMA Test, included with every chemistry panel or as a stand-alone test from IDEXX Reference Laboratories

Note: SDMA is symmetric dimethylarginine.

References

  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  6. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.
  7. International Renal Interest Society. 2015 IRIS CKD Staging Guidelines. www.iris-kidney.com/guidelines. Accessed April 4, 2019