IDEXX Reference Laboratories

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IDEXX 4Dx Plus Test

The accuracy and support you want. The efficiency you need.

The most accurate screening solution available for detecting vector-borne disease—now with IDEXX DecisionIQ for clarity when determining next steps.
  • The standard for detecting heartworm and tick-borne disease
  • Available in-house or from IDEXX Reference Laboratories
  • Supported by peer-reviewed studies as the most accurate screening test available1–3

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Icons of a mosquito and a tick

Detect heartworm antigen (Dirofilaria immitis) and Ehrlichia canis, Ehrlichia ewingii, Ehrlichia chaffeensis, Anaplasma phagocytophilum, Anaplasma platys, and Lyme antibodies (Borrelia burgdorferi infection) in a single blood sample.4,5

Confident diagnosis and management of heartworm and tick-borne disease in a single test


Diagnostic flexibility

In our lab or in your clinic


Superior accuracy

Diagnose with more confidence


Clinical decision support

Clarity to determine next steps


Client communications

Continue the conversation

IDEXX DecisionIQ provides confidence and clarity for determining next steps

You receive a positive test result. Now what?

With expert tools and support included in VetConnect PLUS, you have the information you need to make fast, effective clinical decisions, determine next steps, and communicate recommendations to the client.

Choose how and where you run screening tests

Available in-clinic or from IDEXX Reference Laboratories

Lab 4Dx Plus Test

Available from IDEXX Reference Laboratories:
As a stand-alone test

7244—Lab 4Dx Plus Test

Immunoassay for heartworm antigen, Ehrlichia canis, Ehrlichia ewingii, Ehrlichia chaffeensis, Anaplasma phagocytophilum, Anaplasma platys, and Lyme C6 antibodies

As part of a more complete parasite screen

31804—Fecal Dx Antigen Panel with Lab 4Dx Plus Test—Canine

Lab 4Dx Plus Test, hookworm, roundworm, and whipworm antigens by immunoassay

7230—Heartworm Antigen by Immunoassay Positive Confirmatory
Complimentary after a positive canine or feline heartworm result is obtained in-house using a SNAP Heartworm RT Test, SNAP 4Dx Plus Test, or SNAP Feline Triple Test, or at IDEXX Reference Laboratories using the Lab 4Dx Plus Test.

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SNAP 4Dx Plus Test

Available in-clinic

Reference-laboratory quality in the palm of your hand, for superior diagnostic accuracy at the point of care. Learn more about the SNAP 4Dx Plus Test

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Proven accuracy

Peer-reviewed studies1–3 support that the IDEXX 4Dx Plus Test is the most accurate screening test available, with even better accuracy coming soon

Consistently and accurately detects evidence of infection

Delivers significantly superior sensitivity and specificity

Produces positive results that can be trusted to be true positives

Accuracy matters

Exposure to tick-borne diseases increases the risk of developing chronic kidney disease. Accurate screening tests help detect evidence of infection and accurately reflects the disease status of the patient for confident clinical decisions.

Graphic showing exposure to tick-borne disease increases risk of developing chronic kidney disease

Continuing the conversation with clients on heartworm and tick-borne disease screening

Share these communication resources with your clients to help reinforce the importance of
regular screening to protect their pets and families
Front cover and inside spread of the preventive care brochure for pet owners with dog and cat on front cover from Pet Health Network.
Free client brochures

Educate clients on the importance of their pet's routine wellness visit and how regular screening helps to protect their dogs and families.

Order free brochures

Veterinarian holding mobile phone to show fecal results on VetConnect PLUS with client during his dog's wellness exam.
Client communications with VetConnect PLUS

Celebrate negative results with client-friendly summaries sent directly to pet owners.

Sign in to VetConnect PLUS

Illustration of a phone displaying a social media post for pet routine wellness visits
Social media for ongoing education

Ready-to-go posts to share on your practice's social media channels as well as educational resources to deepen your social media expertise.

Get the free toolkit

U.S. parasite prevalence map
Parasite prevalence maps

Help clients understand the risk of exposure in places they visit and at home.

Explore prevalence maps


Directory of Tests and Services

Browse the online Directory of Tests and Services to see a comprehensive list of offerings from IDEXX Reference Laboratories.

IDEXXCare Plus

Keeping your practice up-to-date and running smoothly is the IDEXXCare Plus promise. We’re at your service 24 hours a day, 7 days a week, to help you deliver the best veterinary care and customer experiences possible.

Five parasites.
Screen for 10 diseases and infections carried by common parasites using IDEXX-exclusive tests

Learn about comprehensive parasite screening with IDEXX Preventive Care

Learn more about the IDEXX 4Dx Plus Test

A representative will help you every step of the way.


  1. Goldstein RE, Eberts MD, Beall MJ, Thatcher B, Chandrashekar R, Alleman AR. Performance comparison of SNAP 4Dx Plus and AccuPlex4 for the detection of antibodies to Borrelia burgdorferi and Anaplasma phagocytophilum. Intern J Appl Res Vet Med. 2014;12(2):141–147.
  2. Eberts MD. Performance of SNAP 4Dx Plus and AccuPlex4 in dogs with different heartworm burdens. Intern J Appl Res Vet Med. 2013;11(1):7–9.
  3. Liu J, Drexel J, Andrews B, Eberts M, Breitschwerdt E, Chandrashekar R. Comparative evaluation of 2 in-clinic assays for vector-borne disease testing in dogs. Top Companion Anim Med. 2018;33(4):114–118. doi:10.1053/j.tcam.2018.09.003
  4. Stillman BA, Monn M, Liu J, et al. Performance of a commercially available in-clinic ELISA for detection of antibodies against Anaplasma phagocytophilum, Anaplasma platys, Borrelia burgdorferi, Ehrlichia canis, and Ehrlichia ewingii and Dirofilaria immitis antigen in dogs. J Am Vet Med Assoc. 2014;245(1):80–86. doi:10.2460/javma.245.1.80
  5. Chandrashekar R, Mainville CA, Beall MJ, et al. Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs. Am J Vet Res. 2010;71(12):1443–1450. doi:10.2460/ajvr.71.12.1443