IDEXX SDMA Test: More reliable kidney function test

Three key attributes make the IDEXX SDMA Test more reliable than creatinine.

  • Biomarker for kidney function
    SDMA is excreted by the kidneys. SDMA more accurately reflects glomerular filtration rate (GFR) in dogs and cats.1-4
  • Earlier than creatinine
    SDMA increases as early as 25% loss of kidney function,2 making SDMA more reliable in both acute or active kidney injury and chronic kidney disease.1-3 Creatinine cannot identify kidney issues until almost 75% of kidney function is lost.2,3
  • Specific for kidney function
    SDMA is less impacted by extrarenal factors than creatinine, including body condition, advanced age, and disease state.5,6

SDMA is also not affected by lean body mass, making it more reliable for assessing kidney function in animals with chronic kidney disease or other conditions that result in weight and muscle loss, such as hyperthyroidism.5,6

SDMA increases when as little as 25% of kidney function has been lost, making it more reliable.

SDMA provides greater reliability for identifying kidney disease in hyperthyroid cats

Hyperthyroidism masks the presence of kidney disease in cats. And, until now, veterinarians have lacked a reliable, routine diagnostic test for assessing kidney function in hyperthyroid cats.

In a recent retrospective data analysis, this test reliably identified 6 times more hyperthyroid cats with kidney disease. Creatinine missed 82% of hyperthyroid cats that the IDEXX SDMA Test identified as having kidney disease.7 Read more >

Case studies

Zeke

Zeke’s creatinine results were influenced by both metabolism and body mass, but an increased SDMA result detected CKD along with his hyperthyroidism. Read more >

Scarlet

Scarlet’s persistently elevated SDMA concentrations led to the diagnosis and early treatment of kidney disease, despite normal creatinine results. Read more >

Bess

Bess’s case highlights the importance of SDMA testing in older patients. SDMA is not influenced by muscle mass and is more reliable than creatinine in detecting kidney disease. Read more >

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References
  1. Nabity MB, Lees GE, Boggess M, et al. Symmetric dimethylarginine assay validation, stability, and evaluation as a marker for early detection of chronic kidney disease in dogs. J Vet Intern Med. 2015;29(4):1036–1044.
  2. Hall JA, Yerramilli M, Obare E, Yerramilli M, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in cats with chronic kidney disease. J Vet Intern Med. 2014;28(6):1676–1683.
  3. Hall JA, Yerramilli M, Obare E, Yerramilli M, Almes K, Jewell DE. Serum concentrations of symmetric dimethylarginine and creatinine in dogs with naturally occurring chronic kidney disease. J Vet Intern Med. 2016;30(3):794–802.
  4. Yerramilli M, Yerramilli M, Obare E, Jewell DE, Hall JA. Symmetric dimethylarginine (SDMA) increases earlier than serum creatinine in dogs with chronic kidney disease (CKD). [ACVIM Abstract NU-42]. J Vet Intern Med. 2014;28(3):1084–1085. Accessed January 14, 2015.
  5. Hall JA, Yerramilli M, Obare E, Yerramilli M, Yu S, Jewell DE. Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides. Vet J. 2014;202(3):588–596.
  6. Hall JA, Yerramilli M, Obare E, Yerramilli M, Melendez LD, Jewell DE. Relationship between lean body mass and serum renal biomarkers in healthy dogs. J Vet Intern Med. 2015;29(3):808–814.
  7. Data on file at IDEXX Laboratories, Inc. Westbrook, Maine USA.