Treating a horse infected with EPM

After an EPM diagnosis is made, use Navigator Paste to kill the parasite in just 28 days1

• Well-established dose
• Consistent, reliable treatment regimen
• Proven performance in horses newly diagnosed with EPM^†
• Proven performance in horses previously treated for EPM^†
• Low relapse rate indicated1

Proven power to heal when managed with care

As with most potent chemotherapies, horses receiving Navigator Paste must be carefully monitored during the treatment period for adverse reactions. As with some antibiotics, the administration of nitazoxanide can disrupt the normal microbial flora of the gastrointestinal tract and lead to enterocolitis and, in some cases, death.

• When treating with Navigator Paste, be sure to obtain an accurate body weight and calculate the dose weekly during treatment. Each Navigator dispensing box includes a weight tape in the first slot with the first dosing syringe. The horse owner should use the weight tape provided or a scale to obtain an accurate body weight for the horse.
• Overdosing of nitazoxanide must be avoided. Read the Dosing & Administration and Precautions sections of the package insert before dosing the horse.

It is important to monitor the horse for adverse clinical signs during the treatment.

• Read the Adverse Reactions section of the package insert for more information on adverse reactions. Each Navigator dispensing box includes a list of possible adverse reactions to monitor on the inside of the lid. There is also a daily treatment diary on the inside flap of the box. The horse owner should use the daily treatment diary to monitor and record observations as the horse progresses through the Navigator treatment.
• Be sure to retain the dispensing box and utilize the treatment diary for recording daily observations until the dosing regimen is completed.
• The following adverse reactions have been reported following the use of nitazoxanide in horses: fever, anorexia/reduced appetite, lethargy/depression, edematous head/limbs, worsening of neurological signs, sore/warm feet, increased digital pulses, colic, decreased gut sounds, scant/loose feces, diarrhea, stiffness, discolored (bright yellow) urine or malodorous/discolored feces, increased water consumption and weight loss. See the Precautions and Adverse Reactions sections of the package insert for a complete list of adverse reactions.
• If a treated horse develops any of the following: a high fever (›103°F), scant or loose feces, diarrhea, colic or signs of laminitis, nitazoxanide treatments should be stopped immediately and appropriate veterinary care should be initiated.
• For more information on adverse reactions read the Adverse Reactions section of the Navigator package insert.

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