NAVIGATOR® Paste—The Mechanism

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NAVIGATOR® (32% nitazoxanide)
Antiprotozoal Oral Paste—The Mechanism

TESTIMONIALS
"My clinic and I have been extremely impressed with the results we have seen using Navigator paste to treat horses with EPM. The drug has earned our respect and is now my first line of treatment for EPM." Dr. Wendy Vaala Read the full testimonial


MORE INFORMATION
Package Insert (245 KB)

Material Safety Data Sheet (60 KB)

Client Sheet (105 KB)

Navigator Paste contains the active ingredient nitazoxanide, which is a 5-nitrothiazole compound and a member of a new class of pyruvate:ferredoxin oxidoreductase (PFOR) inhibitors. Nitazoxanide has been shown to have activity against protozoa, helminths and bacteria in vitro, in animal models or both.

The antiprotozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism. It is probable that nitazoxanide is selectively toxic for organisms capable of intracellular reduction of the nitazoxanide nitro group to a toxic free radical.

The bottom line is—Navigator Paste's mechanism of action "shuts down" cellular respiration of the target organism Sarcocystis neurona to kill the parasite.¹

For more information on Navigator Paste, call IDEXX Customer Support at 1-800-374-8006.

¹	In Field Study II, 81% of the horses were successfully treated. Data submitted to FDA and on file, IDEXX Pharmaceuticals, Inc.
²	Dubey JP, Lindsay DS, Saville WJA, Reed SM, Speer CA. A review of Sarcocystis neurona and equine protozoal myeloencephalitis (EPM). Vet Parasit. 2001;95:89–131.

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Warnings: Administration of nitazoxanide can disrupt the normal microbial flora of the gastrointestinal tract, leading to enterocolitis. Deaths due to enterocolitis have been observed while administering the recommended dose in field studies.

Obtain an accurate body weight and calculate the dose weekly during treatment. Overdosing of nitazoxanide must be avoided. Read the Dosage & Administration and Precautions sections of the package insert before dosing the horse. It is important to monitor the horse for adverse clinical signs during treatment. Read the Adverse Reactions section of the package insert for more information on adverse reactions.

NAVIGATOR® (32% nitazoxanide) Antiprotozoal Oral Paste—The Mechanism

NAVIGATOR® (32% nitazoxanide)
Antiprotozoal Oral Paste—The Mechanism