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Navigator Paste Logo, return to homepage.NAVIGATOR® (32% nitazoxanide)
Antiprotozoal Oral Paste—The Disease

 

Understanding Equine Protozoal Myeloencephalitis (EPM)

Know the risk factors for EPM1

  • Exposure to any site where EPM has been detected previously
  • Grazing pastures and/or feed accessible to other wildlife (especially opossums)
  • Excessive heat that may weaken the immune system
  • Age—especially horses one to five years of age
  • Stressful events, including trailering, breeding, showing, selling, training, foaling and nursing

Know the signs of EPM

Signs of EPM

"This is a devastating disease, and rapidity of diagnosis and treatment is imperative."

Dr. Richard Mitchell
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Client Sheet (105 KB)
 
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View the frequently asked questions
  • Asymmetrical ataxia
  • Lack of coordination that worsens when the head is elevated
  • Stiff, stilted movements
  • Muscle deterioration (hindquarters, muscles of the face or front limbs)
  • Difficulty swallowing or loss of appetite
  • Facial muscular paralysis or loss of sensation
  • Stumbling
  • Seizure
  • Change in personality
  • Fatigue or narcolepsy
  • Head tilt with poor balance
  • Abnormal sweat patterns (focal sweating)
  • Head shaking

For more information on Navigator Paste, call IDEXX Customer Support at 1-800-374-8006.

1 

Saville W, Reed S, Morley P, Granstrom D, Kohn C, Hinchcliff K, Wittum T. Analysis of risk factors for the development of equine protozoal myeloencephalitis in horses. JAVMA. 2000;217:174–180.

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Warnings: Administration of nitazoxanide can disrupt the normal microbial flora of the gastrointestinal tract, leading to enterocolitis. Deaths due to enterocolitis have been observed while administering the recommended dose in field studies.

Obtain an accurate body weight and calculate the dose weekly during treatment. Overdosing of nitazoxanide must be avoided. Read the Dosage & Administration and Precautions sections of the package insert before dosing the horse. It is important to monitor the horse for adverse clinical signs during treatment. Read the Adverse Reactions section of the package insert for more information on adverse reactions.

 
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