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A reliable in-house test for adrenal function
Spontaneous hyperadrenocorticism is a common endocrine disorder in
dogs over six years of age. Diagnosis of this disease should include
evaluation of the history and clinical signs, as well as the resuts of
blood chemistry and screening tests. The most commonly used screening
tests are the ACTH stimulation test and low-dose dexamethasone
suppression test. The ACTH stimulation test can also be used to
monitor the response to treatment and to diagnose hypoadrenocorticism.
SNAP Cortisol Tests allow you to measure cortisol concentrations using
your in-house laboratory, providing the convenience of timely results
and the ability to initiate or modify therapy immediately.
Correlation of the IDEXX SNAP Cortisol Test with
radioimmunoassy*
Each SNAP cortisol lot is tested with canine serum from healthy
animals and from animals being tested for adrenal disease using either
dexamethasone suppression or ACTH stimulation tests. The IDEXX
internal calibration process ensures that each lot of cortisol
maintains a high level of performance and will provide accurate
results for patient samples across all areas of the range.
Hyperadrenocorticism (Cushing's
syndrome)—A diagnosis and the decision to treat should
not be based solely on laboratory testing, but should include the
presence of clinical signs such as polyuria/polydipsia, abdominal
enlargement, alopecia, decreased exercise tolerance, calcinosis cutis,
hyperpigmentation, panting, lethargy and obesity.
Hypoadrenocorticism (Addison's
disease)—It is important to rule out the presenting signs
and symptoms (anorexia, lethargy, depression, vomiting, weakness,
weight loss, diarrhea, dehydration, bradycardia, weak femoral pulse,
waxing/waning symptoms) as being iatrogenic, and include electrolytes,
a physical exam and history when diagnosing Addison's disease. It is
crucial that these signs are identified quickly to prevent or correct
a potential Addisonian crisis.
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The data presented show excellent clinical agreement
between serum cortisol concentrations measured by the SNAP Cortisol
Test and radioimmunoassay (RIA). An r-value of 0.97 indicates
excellent overall agreement between cortisol concentrations measured
by the SNAP test and cortisol concentrations measured by RIA.
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